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"Reduction of total cholesterol (TC) has been an integral part of public health campaigns...
Although disease-specific morbidity and mortality, such as IHD mortality, have their analytical merits, all-cause mortality is arguably the most important endpoint for patients or the general population when assessing risk factors and the effectiveness of a treatment or a public health intervention for life-threatening diseases. The target TC levels for public health interventions in the general population should be determined after careful consideration of the levels associated with the lowest mortality in the general population...
Through a large prospective cohort study among over 12 million participants, we examined whether the association between TC levels and all-cause mortality varied by sex and age, and estimated the sex- and age-specific levels of TC associated with the lowest mortality. Additionally, detailed estimates of the mean (and median) concentrations of TC according to sex and age are presented."