AI scans 400,000 Reddit posts to flag overlooked GLP-1 side effectsby University of Pennsylvania edited by Sadie Harley, reviewed by Robert Egan By using AI to analyze more than 400,000 Reddit posts, Penn researchers have identified patient-reported symptoms associated with GLP-1s, the popular weight-loss and diabetes drugs semaglutide and tirzepatide, that may not be fully captured in clinical trials or regulatory documents. The new study, published in Nature Health, covers more than half a decade of posts from nearly 70,000 Reddit users and highlights two main classes of symptoms that warrant further study: reproductive symptoms, including irregular menstrual cycles, and temperature-related complaints, such as chills and hot flashes. "Some of the side effects we found, like nausea, are well known, and that shows that the method is picking up a real signal," says Sharath Chandra Guntuku, Research Associate Professor in Computer and Information Science (CIS) at Penn Engineering and the study's senior author. "The underreported symptoms are leads that came from patients themselves, unprompted, and clinicians could potentially pay attention to them." "Clinical trials generally identify the most dangerous side effects of drugs," adds Lyle Ungar, Professor in CIS and a co-author on the study. "But they can fail to find what symptoms patients are most concerned about; even though social media is not necessarily representative, a large collection of posts may reflect additional concerns." The researchers caution that their findings are not causal. "We can't say that GLP-1s are actually causing these symptoms," notes Neil Sehgal, the study's first author and a doctoral student in CIS advised by Guntuku and Ungar. "But nearly 4% of the Reddit users in our sample reported menstrual irregularities, which would be even higher in a female-only sample. We think that's a signal worth investigating." Studying social media for healthIn 2011, Ungar participated in one of the earliest efforts to mine online, user-created content for information about drugs' adverse effects. "Online patient communities work a lot like a neighborhood grapevine," says Ungar. "People who are living with these medications are swapping notes with each other in real time, sharing experiences that rarely make it into a doctor's office visit or an official report." In the years since, social media use has only grown, making data from these platforms increasingly promising as a source of information about the side effects of medications, even as the platforms themselves have made accessing the data more difficult. (Guntuku has also published research on strategies for adapting to changes in platform access.) "Clinical trials are the gold standard, but by design, they are slow," says Guntuku. "This is not a replacement for trials, but it can move much faster, and that speed matters when a drug goes from niche to mainstream almost overnight." Leveraging AI to analyze social mediaUntil now, the most challenging part of this process, which Guntuku calls "computational social listening," has been scale. Because users vary in how they describe their symptoms, the effort required to map individual social media posts to language in the Medical Dictionary for Regulatory Activities (MedDRA), which clinicians use to describe symptoms, limited the amount of data this approach could handle. Now, large language models like GPT or Gemini have enabled the systematic analysis of social media posts at an unprecedented scale. "Large language models have made it possible to do this kind of analysis much faster with a level of standardization that could be difficult to achieve before," says Sehgal. Unreported symptomsWhile the population the researchers studied is admittedly not representative—Reddit users are younger, more likely to be male and disproportionately based in the United States—the symptoms described in their collective accounts largely match the known side effects of semaglutide and tirzepatide: about 44% of users in the study described at least one side effect, most commonly some form of gastrointestinal distress. What stood out was the nontrivial percentage of users who reported symptoms that may not be fully reflected in current drug labeling or routine adverse-event reporting. Nearly 4% of users who reported side effects described reproductive symptoms, including menstrual changes such as intermenstrual bleeding, heavy bleeding, and irregular cycles. Others reported temperature-related complaints, such as chills, feeling cold, hot flashes, and fever-like symptoms. In addition, fatigue ranked as the second most common complaint among Reddit users, despite reaching reporting thresholds in relatively few clinical trials. "These drugs are thought to work by engaging part of the brain called the hypothalamus, which helps regulate a wide variety of hormones," says Jena Shaw Tronieri, Senior Research Investigator at Penn's Center for Weight and Eating Disorders and a co-author of the study. "That doesn't mean the medications are necessarily causing these symptoms, but it could suggest that reports of menstrual changes and body temperature fluctuations are worth studying more systematically." Future directionsIn the near term, the researchers hope their findings will encourage clinicians and researchers to take a closer look at the side effects patients are discussing online. "They're clearly on patients' minds, and that's worth paying attention to," says Sehgal. The team also hopes to expand the work beyond Reddit and beyond English-language communities to test whether the same patterns appear across different platforms and populations. "We don't really know yet whether what we're seeing on Reddit reflects the experience of GLP-1 users globally, or whether it's particular to the kind of person who posts on Reddit in the United States," Ungar says. Ultimately, the researchers believe this kind of rapid, AI-assisted social media analysis could become a useful way to spot early warning signs around emerging drugs and wellness trends. For substances that trend quickly online, especially those sold in loosely regulated or unregulated markets, like injectable peptides, patient discussions on platforms like Reddit and TikTok may offer one of the earliest clues to what users are actually experiencing. "The whole point of this kind of approach is that it can move quickly, and that's exactly when it's most valuable," says Guntuku. ARTICLE SOURCE: https://medicalxpress.com/news/2026-04-ai-scans-reddit-flag-overlooked.html
Where have all the vegans gone?
Over a decade after the first Veganuary, Americans are eating more meat. Has the plant-based movement become a casualty of the pushback against ‘wokeness’?
Laura Pitcher
Growing up in a vegetarian household, I was aware that being plant-based was deeply uncool for most of my younger years. Then came Veganuary in 2014. In the years that followed, everyone from (albeit dangerous) wellness influencers like Freelee The BananaGirl to celebrities like Arnold Schwarzenegger and Beyoncé were talking about veganism. By 2019, a year The Economist declared “The Year of the Vegan”, meat alternatives were trending: Beyond Meat went public and Impossible Foods scored deals with places like Burger King. Almost all of my friends were switching to oat or almond milk, and even asking for advice on vegan recipes. In that moment, amid a rising interest in the environmental impact of meat consumption and with new technology on the horizon, it felt like plant-based options were the future.
Until they weren’t – instead, in recent years, vegan restaurants have been shutting down and sales of beef, pork, lamb, poultry and other meats have hit record highs. On average, Americans ate nearly 7 per cent more meat in 2024 than before the pandemic, and, despite claims that veganism is still growing, only one per cent of Americans said they are vegan in 2023, down from 3 per cent in 2018. Living in New York, it’s a shift I’ve felt throughout the past couple of years, but it’s not just happening in America: In 2023, the number of people identifying as vegan had dropped by 29 per cent in Europe and 15 per cent in the UK.
As someone who went vegan in a time when very few alternatives existed, I perhaps got too comfortable with the new array of plant-based products hitting the shelves. As fast as they came, some are already disappearing from my local supermarkets and restaurants, as other vegans on Reddit and Facebook check in with each other across the country: “Are vegan meat substitutes disappearing off the shelf where you live?”. “At its peak, there were substitutes for almost everything: tiramisu, chicken nuggets, smoked salmon alternatives, cheeses, all of it,” says Julia Karolak, a 25-year-old in Switzerland. “But luxury items were the first to go, vegan chocolate is getting harder to find and baked goods, desserts and specialty items that were common a couple of years ago are suddenly gone.”
Edinburgh-based lifestyle creator Sophia Slater, otherwise known as “Vegan Soph”, has been vegan since 2019. “Before that, I was a vegetarian for about six months, but the goal was always to be vegan; I just needed to ease my way into it,” she says. The introduction of vegan products, like Gregg’s iconic vegan sausage roll, the same year, helped. “That absolutely shook up the vegan scene and made vegan options on the high street a lot more accessible,” she says. Recently, Slater says there’s been outrage in the vegan community over the removal of Marks & Spencer’s dedicated Plant Kitchen section, and Wagamama cutting Vegatsu and more from their vegan menu. “Even just going to the supermarket now, it’s like, ‘Oh that’s gone’,” says Slater. “It’s been happening slowly but surely, which is sad to see.”
Veganism or vegetarianism has existed in multiple cultures and countries throughout history, and I have no doubt it will continue to do so. The current revolt, it seems, is against the puritanical PETA-pilled, white, wellness-infused type of veganism. The culture of putting animals over people, of extremes over empathy, is something I understand is off-putting – I am often not deemed vegan “enough” by extreme vegans because I buy secondhand leather. But today, the stereotype of veganism has gone beyond being annoying to being a symbol of “wokeness”. “The pendulum has swung back toward conservatism, and that shift makes veganism feel like part of a progressive package people currently want distance from,” says Karolak.
In the age of Robert F Kennedy Jr’s Make America Healthy Again push towards whole, “unprocessed” animal products, a more animal-based diet has become mainstream, even to many of those who lean left. There’s a growing fear around ultra-processed foods. Also, there’s the fact that, thanks to meat and dairy lobbying, plant-based meat and milks are far more expensive than their animal-based counterparts, making veganism inaccessible for many. But it’s also not exactly a stretch to link the current conservative shift to the declining interest in a plant-based diet: studies have shown that conservatism predicts lapses from vegetarian and vegan diets to meat consumption. Even Peter McGuinness, the current CEO of Impossible Foods, has said that the plant-based sector became too “woke” and “political” for mass appeal.
When discussing the link between conservatism and attitudes towards veganism, we have to talk about gender. More specifically, the stereotype that “real men eat meat”, while plant-based men are weak “soy boys”. Elina Vrijsen, a PhD Candidate researching the cultural construction of masculinity in relation to meat consumption at the University of Antwerp, says that the idea that meat is a necessary part of the daily meal (instead of a luxury) has only existed for broad parts of the population since the 20th century. “The link between meat and masculinities was possibly reinforced during the World Wars when there was a rationing system for food, and meat was prioritised for soldiers and working men, under the assumption that they ‘needed’ it for strength and endurance,” she says. “Women, children, and civilians often received less meat.”
Flash forward to today, and the post-war cultural narrative that meat is essential for masculinity lives on in manosphere creators who are serving up steak and raw butter on wooden chopping boards online. Vrijsen says the rise of modern fitness culture has often presented meat as an essential part of building a muscular body. “The idea that veganism is ‘feminine’ stems from the fact that food – just like many other elements of social life – is deeply gendered,” says Vrijsen. “Part of this stereotype comes from longstanding assumptions about appetite and bodily needs.” None of this is a surprise if you’re a woman who has had the experience of telling men you are vegan – from countless lectures about protein to threats of hiding meat in dishes, some men make a routine out of having opinions on what women choose to do and consume.
There’s also framing of veganism as being gentle or nurturing, traditionally feminine traits, and positioned in contrast to more traditional societal norms. During a time when right-wing nationalist parties across the world are talking about a return to tradition, this push has included more meat on plates. Although the link has not been studied yet, Vrijsen says traditional notions of gender often go hand-in-hand with more conservative political beliefs, and research suggests that men who identify more strongly with traditional ideas of masculinity also tend to consume more meat. “In Belgium, conservative politician Guy D’haeseleer has used meat symbolically in his messaging, positioning the abolition of halal meat and the return of ‘traditional Flemish food’ as campaign points,” Vrijsen says. “In that framework, eating meat becomes a symbol of stability, heritage and resistance to social change – a cultural and political boundary marker.”
Meat consumption becoming a symbol of resistance to “wokeness”, of course, does not mean that if you simply eat meat, you are conservative, or that all vegans are progressive. “It’s less about the food itself and more about the political symbolism that different groups project onto it,” says Vrijsen. “The term ‘plant-based’ functions as a rhetorical tool – used strategically to polarize debates around identity, gender and social change.” It’s a battle that takes place in restaurants and supermarkets, often without our awareness. Under capitalist systems, buying plant-based or animal-based products – whichever is trending – is sold not just as a product, but as an identity to consume.
For now, and once again, vegans are out of vogue. To some, it’s a relief to no longer be in the spotlight. “In a strange way, daily life has actually become easier now that people mostly dismiss it rather than challenge it,” says Karolak. “Visibility increased, but respect didn’t necessarily follow, so when veganism was at a peak, people seemed almost personally offended by it.” There’s also the fact that a slowdown in hype over vegan food does not necessarily indicate a decline in interest for good. “It may simply mean that plant-based eating is becoming more familiar and integrated into everyday food culture,” says Vrijsen. There are still new plant-based products being released, after all.
Other once hopeful vegans like myself are still reminiscing on the moment when it felt like a more plant-based future was possible. “From 2014 to 2019 was a very encouraging and exciting time that made us feel like we were finally making some progress,” says Nzinga Young, a vegan influencer in Cleveland, who went vegan as part of her Vipassana meditation practice. “I was getting attention for being vegan and a Black woman, so I was ‘super woke’ and pandemic brand deals followed.” Now, Young says there’s been a shift in opportunities for vegan creators. She’s worked with brands to promote vegan options, only to have them remove them shortly after.
“In January, after the recent election, I knew veganism would become less popular and things would significantly change,” says Young. And they already have, at least until a new wave of mainstream vegan interest – hopefully accompanied by a more welcoming rebrand of what it means to eat more plant-based.
ARTICLE SOURCE: https://www.dazeddigital.com/life-culture/article/69135/1/where-have-all-the-vegans-gone-wokeness-plant-based-diet
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