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This is a really great video and definitely something anyone should watch and understand if they’re considering trying keto or sugar fasting.

In the video, Nick Norwitz explains that both high-carb, low-protein (sugar fasting) and high-fat, low-protein (keto) diets elevate FGF21, which is the hormone responsible for increasing fat metabolism by raising energy expenditure. He also notes that genetic variants in FGF21 are extremely common—present in about 44% of people. If you have one of these variants, your FGF21 levels may not increase as expected on either diet, which means you might not experience the same rise in energy expenditure—and could even gain weight.

So why does he only offer caution about the sugar diet? That seems incredibly biased. I believe the same level of caution should be applied to keto as well, especially since, by his own explanation, the mechanism behind weight loss and increased energy expenditure is the same—FGF21. He also mentions that obesity is a state in which FGF21 resistance is likely. So, if you're obese and part of the 44% with a genetic variant, it’s very possible that neither of these diets will work as intended. Based on his interpretation of the study, the warning he gives about the sugar diet should absolutely apply to keto too.

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